sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis
PLoS neglected tropical diseases2017Vol. 11(3), pp. e0005486–e0005486
Citations Over TimeTop 11% of 2017 papers
Ricardo Luís Louzada da Silva, Márcio Bezerra‐Santos, Priscila L. S. Almeida, Thayse S. Barros, Lucas Sousa Magalhães, Rodrigo Anselmo Cazzaniga, Patricia Souza, Nívea F. Luz, Jaqueline França‐Costa, Valéria M. Borges, Djalma S. Lima‐Junior, Michael W. Lipscomb, Malcolm S. Duthie, Steven G. Reed, Roque Pacheco de Almeida, Amélia Ribeiro de Jesus
Abstract
Taken together, our results reveal sCD163 as a potential biomarker of severity of diseases caused by intracellular pathogens M. leprae and Leishmania spp. and have a modulatory role, with a mix of an inflammatory property induced by TNF-α release, but that potentially induces an anti-inflammatory T cell response, related to IL-4 release.
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