GDNF Secreting Human Neural Progenitor Cells Protect Dying Motor Neurons, but Not Their Projection to Muscle, in a Rat Model of Familial ALS
PLoS ONE2007Vol. 2(8), pp. e689–e689
Citations Over TimeTop 1% of 2007 papers
Masatoshi Suzuki, Jacalyn McHugh, Craig Tork, Brandon Shelley, Sandra Klein, Patrick Aebischer, Clive N. Svendsen
Abstract
The potential to maintain dying motor neurons by delivering GDNF using neural progenitor cells represents a novel and powerful treatment strategy for ALS. While this approach represents a unique way to prevent motor neuron loss, our data also suggest that additional strategies may also be required for maintenance of neuromuscular connections and full functional recovery. However, simply maintaining motor neurons in patients would be the first step of a therapeutic advance for this devastating and incurable disease, while future strategies focus on the maintenance of the neuromuscular junction.
Related Papers
- → Beta-Catenin Signaling Negatively Regulates Intermediate Progenitor Population Numbers in the Developing Cortex(2010)74 cited
- → Pancreatic Progenitor Cells—Recent Studies(2008)25 cited
- → Tcf7l1 is required for spinal cord progenitor maintenance(2011)11 cited
- → Defining the contribution of Troy-positive progenitor cells to the mouse esophageal epithelium(2024)7 cited
- → Neural progenitors and stem cells: mechanisms of progenitor heterogeneity(1998)93 cited