Assessment of BED HIV-1 Incidence Assay in Seroconverter Cohorts: Effect of Individuals with Long-Term Infection and Importance of Stable Incidence
PLoS ONE2011Vol. 6(3), pp. e14748–e14748
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Janet M. McNicholl, J. Steven McDougal, Punneeporn Wasinrapee, Bernard M. Branson, Michael Martin, Jordan W. Tappero, Philip A. Mock, Timothy A. Green, Dale J. Hu, Bharat Parekh, for the Thai-U.S. BED Assay Validation Working Group
Abstract
Evaluation of the performance of incidence assays requires the inclusion of a substantial number of cohort-derived specimens from individuals with long-term HIV infection and, ideally, the use of cohorts in which incidence remained stable. Appropriate adjustments of the BED incidence estimates generate estimates similar to those generated conventionally.
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