Resveratrol Inhibits Inflammatory Responses via the Mammalian Target of Rapamycin Signaling Pathway in Cultured LPS-Stimulated Microglial Cells
PLoS ONE2012Vol. 7(2), pp. e32195–e32195
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Lianmei Zhong, Yi Zong, Lin Sun, Jiazhi Guo, Wei Zhang, Ying He, Rui Song, Wen‐Min Wang, Chunjie Xiao, Di Lü
Abstract
This study indicates that resveratrol inhibited LPS-induced proinflammatory enzymes and proinflammatory cytokines via down-regulation phosphorylation of NF-κB, CREB and MAPKs family in a mTOR-dependent manner. These findings reveal, in part, the molecular basis underlying the anti-inflammatory properties of resveratrol.
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