Atorvastatin Enhance Efficacy of Mesenchymal Stem Cells Treatment for Swine Myocardial Infarction via Activation of Nitric Oxide Synthase
PLoS ONE2013Vol. 8(5), pp. e65702–e65702
Citations Over TimeTop 10% of 2013 papers
Lei Song, Yue-Jin Yang, Qiu-Ting Dong, Hai-Yan Qian, R Gao, Shu-bin Qiao, Rui Shen, Zuo-Xiang He, Minjie Lu, Shihua Zhao, Yong-Jian Geng, Bernard J. Gersh
Abstract
Atorvastatin facilitates survival of implanted MSCs, improves function and morphology of infarcted hearts, mediated by activation of eNOS and alleviated by NOS inhibitor. The data reveal the cellular and molecular mechanism for anti-AMI therapy with a combination of statin and stem cells.
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