Investigation of mobile genetic elements and their association with antibiotic resistance genes in clinical pathogens worldwide
PLoS ONE2025Vol. 20(8), pp. e0330304–e0330304
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Markus Hans Kristofer Johansson, Thomas Nordahl Petersen, Sidsel Nag, Timmie Mikkel Lagermann, Laura Elmlund Kohl Birkedahl, Silva Tafaj, Susan Bradbury, Peter Collignon, Denise A Daley, Victorien Dougnon, Kafayath Fabiyi, Boubacar Coulibaly, Réné Dembelé, Natama Magloire, Isidore Juste Ouindgueta, Zenat Zebin Hossain, Anowara Begoum, Deyan Donchev, Mathew Diggle, LeeAnn Turnbull, Simon Lévesque, Livia Berlinger, Kirstine K. Søgaard, Paula Díaz, Carolina de Albuquerque Lima Duarte, Panagiota Maikanti, Jana Amlerová, Pavel Dřevı́nek, Jan Tkadlec, Milica Dilas, Achim J. Kaasch, Henrik Westh, Mohamed Azzedine Bachtarzi, Wahiba Amhis, Carolina Elisabeth Satán Salazar, José E. Villacís, M.Á. Domínguez, Dàmaris Berbel, Claire Duployez, Maxime Paluch, Solomon Asante-Sefa, Mie Møller, Margaret Ip, Ivana Mareković, Ágnes Sonnevend, Clementina Cocuzza, Asta Dambrauskienė, Alexandre Macanze, Anélsio Cossa, Inácio Mandomando, Philip Nwajiobi-Princewill, Iruka N. Okeke, Aderemi Kehinde, Ini Adebiyi, Ifeoluwa Akintayo, Oluwafemi Popoola, Anthony Onipede, Anita Blomfeldt, Nora Elisabeth Nyquist, Kiri Bocker, James E. Ussher, Amjad Ali, Nimat Ullah, Habibullah Khan, Natalie Weiler Gustafson, Ikhlas Jarrar, Arif Al-Hamad, Viravarn Luvira, Wantana Paveenkittiporn, Irmak Baran, James Mwansa, Linda Sikakwa, Kaunda Yamba, Frank M. Aarestrup
Abstract
Resistance genes are spread through various MGEs, including plasmids and transposons. Our findings suggest that multiple factors influence MGE prevalence and their transposability, thereby shaping the MGE population and transmission pathways. Some MGEs have a wider host range, which could make them more important for mobilizing genes. We also identified 103 resistance genes potentially mobilised by MGEs, which could increase their transmissibility to unrelated bacteria.
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