Presence of Donor-Derived DNA and Cells in the Urine of Sex-Mismatched Hematopoietic Stem Cell Transplant Recipients: Implication for the Transrenal Hypothesis
Clinical Chemistry2008Vol. 55(4), pp. 715–722
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Emily C W Hung, Tristan K F Shing, S Chim, Philip Chun Yeung, Rebecca W.Y. Chan, Ki Wai Chik, Vincent Lee, Nancy B. Y. Tsui, Chi Kong Li, Sze Chuen Cesar Wong, Rossa W. K. Chiu, Yuk Ming Dennis Lo
Abstract
This report is the first to demonstrate the presence of donor-derived DNA in the urine of HSCT recipients; however, we show that much of this DNA originates from donor-derived cells, rather than from the transrenal passage of cell-free plasma DNA. Our discovery of donor-derived cytokeratin-producing epithelial cells raises interesting biological and therapeutic implications, e.g., the capacity of marrow stem cells to serve as an extrarenal source for renal tubule regeneration.
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