Altered thermoregulatory responses in heart failure patients exercising in the heat

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Abstract

Heart failure (HF) patients appear to exhibit impaired thermoregulatory capacity during passive heating, as evidenced by diminished vascular conductance. Although some preliminary studies have described the thermoregulatory response to passive heating in HF, responses during exercise in the heat remain to be described. Therefore, the aim of this study was to compare thermoregulatory responses in HF and controls (CON) during exercise in the heat. Ten HF (NYHA classes I-II) and eight CON were included. Core temperature (T_c), skin temperature (T_sk), and cutaneous vascular conductance (CVC) were assessed at rest and during 1 h of exercise at 60% of maximal oxygen uptake. Metabolic heat production (H_prod) and the evaporative requirements for heat balance (E_req) were also calculated. Whole-body sweat rate was determined from pre-post nude body mass corrected for fluid intake. While H_prod (HF: 3.9 ± 0.9; CON: 6.4 ± 1.5 W/kg) and E_req (HF: 3.3 ± 0.9; CON: 5.6 ± 1.4 W/kg) were lower (P c (HF: 0.9 ± 0.4; CON: 1.0 ± 0.3°C). Despite this similar rise in T_c, T_sk (HF: 1.6 ± 0.7; CON: 2.7 ± 1.2°C), and the elevation in CVC (HF: 1.4 ± 1.0; CON: 3.0 ± 1.2 au/mmHg) was lower (P < 0.05) in HF compared to CON Additionally, whole-body sweat rate (HF: 0.36 ± 0.15; CON: 0.81 ± 0.39 L/h) was lower (P = 0.02) in HF compared to CON Patients with HF appear to be limited in their ability to manage a thermal load and distribute heat content to the body surface (i.e., skin), secondary to impaired circulation to the periphery.

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