CTL escape - progress in identifying therapeutic avenues to control HIV viraemia
Abstract
The central role of HIV-specific cellular immunity in controlling HIV replication is now established. Knowledge of how the virus in the majority of infected persons successfully evades these immune responses is critical to vaccine design. Virus escape from recognition by HIV-specific cytotoxic T-lymphocyte (CTL) responses has been a contentious issue for almost a decade, but recent data from the SIV macaque model of HIV infection suggest that CTL escape is a major factor in AIDS pathogenesis. This review describes the challenges to investigating CTL escape in HIV infection, and discusses the implications of recent studies in macaques and humans to improving our understanding of how effective immune-mediated control of HIV may ultimately be achieved.
Related Papers
- Immunologic and pathologic manifestations of the infection of rhesus monkeys with simian immunodeficiency virus of macaques.(1990)
- → Simian immunodeficiency virus (SIV)-specific CTL in cerebrospinal fluid and brains of SIV-infected rhesus macaques.(1995)64 cited
- → 1 H Magnetic Resonance Spectroscopy Reveals Neuronal Injury in a Simian Immunodeficiency Virus Macaque Model(1997)33 cited
- → Simple and Choice Reaction Time Performance in SIV-Infected Rhesus Macaques(1999)26 cited
- → Identification of SIV env‐specific CTL in the jejunal mucosa in vaginally exposed, seronegative rhesus macaques (Macaca mulatta)(2000)30 cited