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Preventive Effect on Stroke of a Calcium Antagonist and Its Mechanisms in SHR
Japanese Heart Journal1984Vol. 25(5), pp. 908–908
Yasuo Nara, Motoki Tagami, Katsumi Ikeda, Masayuki Mano, Masahiro Kihara, Ryoichi Horie, Yukio Yamori
Abstract
In SHR, a Ca2+ antagonist, Diltiazem significantly reduced the incidence of stroke. Thymidine incorporation into cultured smooth muscle cells was suppressed by 10-4 M Diltiazem, so that strain difference disappeared. By autoradiogram Diltiazem was observed in cardiomyocyte organella and tended to concentrate finally on mitochondria.
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