A 12-Year Prospective Study of Childhood Herpes Simplex Encephalitis: Is There a Broader Spectrum of Disease?
PEDIATRICS2007Vol. 119(2), pp. e399–e407
Citations Over TimeTop 10% of 2007 papers
Jorina Elbers, Ari Bitnun, Susan E. Richardson, Elizabeth Ford-Jones, Raymond Tellier, Rachel M. Wald, Martin Petric, Hanna Kolski, Helen Heurter, Daune MacGregor
Abstract
Herpes simplex encephalitis continues to be associated with poor long-term neurologic outcomes despite appropriate therapy. Cerebrospinal fluid polymerase chain reaction results may be negative early in the course of herpes simplex encephalitis; therefore, repeat cerebrospinal fluid analysis should be considered if herpes simplex encephalitis is suspected. Atypical forms of herpes simplex virus central nervous system disease may occur in children.
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