Stromal fibroblasts and invasive cancer growth
Kazan medical journal1988Vol. 69(3), pp. 220–221
Abstract
Stromal fibroblasts from 230 cancerous tumors of different localization were studied. Fibroblasts were located in the stroma of cancerous tumors relatively uniformly - on average 2430.9 133.7 per 1 mm2 stroma, but since the stroma occupied only a part of tumors, the number of fibroblasts per 1 mm2 histological preparation of neoplasm was somewhat lower and varied from 58.1 to 2772.0 (on average 1114.4 107.8), and in some cases fibroblasts were the prevailing cell type. The axial orientation of these stromal cells, especially in the areas of mature stroma, mostly coincided with the direction of collagen fiber bundles, and in the areas of edematous and disorganized connective tissue was often chaotic.
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