Developing an Electrically Sensitive Ultrasound Enhancing Agent
2020
Michael Cimorelli, Steven P. Wrenn
Abstract
In this work, a novel class of ultrasound enhancing agent (UEA) is developed and characterized in vitro and in vivo. This novel class of UEA combines phase change agents (PCAs) and a nested architecture to create a nested PCA (NPCA). PCAs are sub-micron liquid spheres encapsulated by a surfactant coating that acoustically vaporize, becoming echogenic, upon exposure to sufficient ultrasonic energy. Nesting is performed via a double emulsion synthesis that results in the formation of a phospholipid bilayer that encapsulates an internal aqueous phase. The objective of creating an NPCA is to address short comings and clinical limitations of current U.S. Food and Drug Administration (FDA)-approved UEAs.
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