Tanshinone IIA mediates SMAD7-YAP interaction to inhibit liver cancer growth by inactivating the transforming growth factor beta signaling pathway
Aging2019Vol. 11(21), pp. 9719–9737
Citations Over TimeTop 16% of 2019 papers
Lifang Ma, Hongyuan Jiang, Xin Xu, Congcong Zhang, Yongjie Niu, Zhixian Wang, Yuquan Tao, Yan Li, Feng Cai, Xiao Zhang, Xinghe Wang, Yongchun Yu
Abstract
Tanshinone IIA (TanIIA)-an active constituent of Salvia miltiorrhiza, a traditional Chinese medicinal plant-is known to have blood circulation promotion and anti-tumor properties. Tan IIA can induce tumor cell death and inhibit tumor growth. However, the functions and underling molecular mechanisms of Tan IIA action on human liver cancer cells remain poorly understand. In this study, we found that Tanshinone IIA mediates SMAD7-YAP interaction to induce liver cancer cell apoptosis and inhibit cell growth and migration by inactivating the transforming growth factor beta (TGF-β) signaling pathway. Our findings showed that the Tan IIA-SMAD7-YAP regulatory network might be an effective strategy for liver cancer treatment.
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