G6PC3, ALDOA and CS induction accompanies mir-122 down-regulation in the mechanical asphyxia and can serve as hypoxia biomarkers

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Abstract

// Yan Zeng 1 , Yehui Lv 1,2 , Li Tao 1 , Jianlong Ma 1 , Heng Zhang 1,3 , Hongmei Xu 1 , Bi Xiao 4 , Qun Shi 4 , Kaijun Ma 4 and Long Chen 1 1 Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, People’s Republic of China 2 Shanghai University of Medicine & Health Sciences, Shanghai, People’s Republic of China 3 Department of Physiology & Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, People’s Republic of China 4 Forensic Lab, Criminal Science and Technology Institute, Shanghai Public Security Bureau, Shanghai, People’s Republic of China Correspondence to: Long Chen, email: // Kaijun Ma, email: // Keywords : hypoxia; mechanical asphyxia; mir-122;G6PC3; ALDOA; Gerotarget Received : August 19, 2016 Accepted : October 22, 2016 Published : October 26, 2016 Abstract Hypoxia influences different cellular biological processes. To reveal the dynamics of hypoxia’s effects on miRNA regulation in vivo , we examined the expression levels of all miRNAs in human brain and heart specimens from cases of mechanical asphyxia compared with those from cases of craniocerebral injury and hemorrhagic shock. We further validated differently expressed miRNAs in another 84 human specimens and rat models. We found that mir-122 was significantly down-regulated and that its putative targets G6PC3 , ALDOA and CS were increased in the brain and cardiac tissues in cases of mechanical asphyxia compared with craniocerebral injury and hemorrhagic shock. Our data indicate that mir-122 and its targets G6PC3 , ALDOA and CS play roles in the hypoxia responses that regulate glucose and energy metabolism and can serve as hypoxia biomarkers.

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