Upregulation of mucin glycoprotein MUC1 in the progression to esophageal adenocarcinoma and therapeutic potential with a targeted photoactive antibody-drug conjugate
Oncotarget2017Vol. 8(15), pp. 25080–25096
Citations Over TimeTop 24% of 2017 papers
Mohammed A. Butt, Hayley Pye, Rehan Haidry, Dahmane Oukrif, Saif-U-Rehman Khan, Ignazio Puccio, Michael Gandy, Halla W. Reinert, Ellie Bloom, Mohammed Rashid, Gökhan Yahioglu, Mahendra P. Deonarain, Rifat Hamoudi, Manuel Rodriguez‐Justo, Marco Novelli, Laurence Lovat
Abstract
MUC1 is a promising target in EA. Molecular and light based targeting of MUC1 with a photosensitive ADC is effective in vitro and after development may enable treatment of locoregional tumors endoscopically.
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