Intratumoral heterogeneity and TERT promoter mutations in progressive/higher-grade meningiomas
Oncotarget2017Vol. 8(65), pp. 109228–109237
Citations Over TimeTop 10% of 2017 papers
Tareq A. Juratli, Christian Thiede, Mara V.A. Koerner, Shilpa S. Tummala, Dirk Daubner, Ganesh M. Shankar, Erik A. Williams, María Martínez-Lage, Silke Soucek, Katja Robel, Tristan Penson, Mechthild Krause, Steffen Appold, Matthias Meinhardt, Thomas Pinzer, Julie J. Miller, Dietmar Krex, Heather A. Ely, Ian M. Silverman, Jason Christiansen, Gabriele Schackert, Hiroaki Wakimoto, Matthias Kirsch, Priscilla K. Brastianos, Daniel P. Cahill
Abstract
In progressive/higher-grade meningiomas,TERTp mutations are associated with poor survival, supporting a model in which selection of this alteration is a harbinger of aggressive tumor development. In addition, we observe spatial intratumoral heterogeneity of TERTp mutation status, consistent with this model of late emergence in tumor evolution. Thus, early detection of TERTp mutations may define patients with more aggressive meningiomas. Stratification for TERT alterations should be adopted in future clinical trials of progressive/higher-grade meningiomas.
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