Vitamin D receptor as a marker of prognosis in oesophageal adenocarcinoma: a prospective cohort study
Oncotarget2018Vol. 9(76), pp. 34347–34356
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Stephen McCain, James Trainor, Damian McManus, Úna C. McMenamin, Stephen McQuaid, Victoria Bingham, Jacqueline A. James, Manuel Salto‐Tellez, Richard Turkington, Helen G. Coleman
Abstract
Oesophageal adenocarcinoma specimens and clinical data were collected from 130 patients treated with neo-adjuvant chemotherapy prior to surgical resection at the Northern Ireland Cancer Centre between 2004 and 2012. Tissue microarrays were created and immunohistochemical staining for VDR was performed on triplicate tumour cores from each resection specimen. Cox proportional hazards models were applied to evaluate associations between VDR, according to tertiles of expression, and survival outcomes.
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