Cardamonin reduces chemotherapy-enriched breast cancer stem-like cellsin vitroandin vivo
Citations Over TimeTop 10% of 2015 papers
Abstract
The failure of cytotoxic chemotherapy in breast cancers has been closely associated with the presence of drug resistant cancer stem cells (CSCs). Thus, screening for small molecules that selectively inhibit growth of CSCs may offer great promise for cancer control, particularly in combination with chemotherapy. In this report, we provide the first demonstration that cardamonin, a small molecule, selectively inhibits breast CSCs that have been enriched by chemotherapeutic drugs. In addition, cardamonin also sufficiently prevents the enrichment of CSCs when simultaneously used with chemotherapeutic drugs. Specifically, cardamonin effectively abolishes chemotherapeutic drug-induced up-regulation of IL-6, IL-8 and MCP-1 and activation of NF-κB/IKBα and Stat3. Furthermore, in a xenograft mouse model, co-administration of cardamonin and the chemotherapeutic drug doxorubicin significantly retards tumor growth and simultaneously decreases CSC pools in vivo. Since cardamonin has been found in some herbs, this work suggests a potential new approach for the effective treatment of breast CSCs by administration of cardamonin either concurrent with or after chemotherapeutic drugs.
Related Papers
- → TWO LOCI SELECTIVELY EXPRESSED ON FUNCTIONALLY DIFFERENT T CELLS**This work was supported by grants from the Ministry of Education, Science and Culture and the Ministry of Health, Japan(1978)5 cited
- → Book Review: IV. Ministry Studies: Black and White Styles of Youth Ministry: Two Congregations in America(1995)
- → Book Review: The Life of Our Lord, The Life and Ministry of Jesus, Jesus and His Ministry(1955)
- → Book Review: IV. Historical—Theological Studies: The Ministry and the Ministry of Women(1972)
- → Book Review: III. Ministry Studies: 21 Bridges to the 21st Century: The Future of Pastoral Ministry(1994)