BAP1 suppresses lung cancer progression and is inhibited by miR-31

Citations Over TimeTop 10% of 2016 papers

Abstract

BRCA1-associated protein-1 (BAP1) is an important nuclear-localized deubiquitinating enzyme that serves as a tumor suppressor in lung cancer; however, its function and its regulation are largely unknown. In this study, we found that BAP1 protein levels were dramatically diminished in lung cancer tissues while its mRNA levels did not differ significantly, suggesting that a post-transcriptional mechanism was involved in BAP1 regulation. Because microRNAs (miRNAs) are powerful post-transcriptional regulators of gene expression, we used bioinformatic analyses to search for miRNAs that could potentially bind BAP1. We predicted and experimentally validated miR-31 as a direct regulator of BAP1. Moreover, we showed that miR-31 promoted proliferation and suppressed apoptosis in lung cancer cells and accelerated the development of tumor growth in xenograft mice by inhibiting BAP1. Taken together, this study highlights an important role for miR-31 in the suppression of BAP1 in lung cancer cells and may provide insights into the molecular mechanisms of lung carcinogenesis.

Related Papers

• → China and the Challenge of Economic Globalization: The Impact of WTO Membership. Hung-Gay Fung , Changhong Pei , Kevin H. Zhang(2007)
• → Whither China? Intellectual Politics in Contemporary China. Edited by Xudong Zhang. Durham: Duke University Press, 2001. 400 pp. $23.95 (paper).(2003)
• → Catch-up and Competitiveness in China: The Case of Large Firms in the Oil Industry. Jin Zhang(2005)
• → From Underground to Independent: Alternative Film Culture in Contemporary China. Paul G. Pickowicz , Yingjin Zhang(2007)
• → Whither China? Intellectual Politics in Contemporary China. Xudong Zhang(2003)