The non-coding landscape of head and neck squamous cell carcinoma

Citations Over TimeTop 10% of 2016 papers

Abstract

Head and neck squamous cell carcinoma (HNSCC) is an aggressive disease marked by frequent recurrence and metastasis and stagnant survival rates. To enhance molecular knowledge of HNSCC and define a non-coding RNA (ncRNA) landscape of the disease, we profiled the transcriptome-wide dysregulation of long non-coding RNA (lncRNA), microRNA (miRNA), and PIWI-interacting RNA (piRNA) using RNA-sequencing data from 422 HNSCC patients in The Cancer Genome Atlas (TCGA). 307 non-coding transcripts differentially expressed in HNSCC were significantly correlated with patient survival, and associated with mutations in TP53, CDKN2A, CASP8, PRDM9, and FBXW7 and copy number variations in chromosomes 3, 5, 7, and 18. We also observed widespread ncRNA correlation to concurrent TP53 and chromosome 3p loss, a compelling predictor of poor prognosis in HNSCCs. Three selected ncRNAs were additionally associated with tumor stage, HPV status, and other clinical characteristics, and modulation of their expression in vitro reveals differential regulation of genes involved in epithelial-mesenchymal transition and apoptotic response. This comprehensive characterization of the HNSCC non-coding transcriptome introduces new layers of understanding for the disease, and nominates a novel panel of transcripts with potential utility as prognostic markers or therapeutic targets.

Related Papers

• → Association of T P53 and CDKN2A Mutation Profile with Tumor Mutation Burden in Head and Neck Cancer(2022)85 cited
• → Circulating MicroRNA and Long Noncoding RNA as Biomarkers of Cardiovascular Diseases(2015)68 cited
• → Long Noncoding RNAs in Metabolic Syndrome Related Disorders(2016)76 cited
• → Antisense-Mediated Reduction of Eukaryotic Noncoding RNAs(2012)4 cited
• The dichotomy of p53 regulation by noncoding RNAs(2014)