Monocyte galactose/N-acetylgalactosamine-specific C-type lectin receptor stimulant immunotherapy of an experimental glioma. Part II: combination with external radiation improves survival
Cancer Management and Research2012Vol. 4, pp. 325–325
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Mark C. Preul, Philip C. Wiener, Tejas Sankar, Laura L. Eggink, Yevgeniya Kushchayeva, J. Kenneth Hoober, Jennifer Eschbacher, Ruolan Liu, Fu‐Dong Shi, Mohammed G. Abdelwahab, Adrienne C. Scheck, Preul
Abstract
Specific populations of monocyte-derived brain cells develop critical relationships with malignant gliomas. The biological effect of GCLRP in combination with radiation may be more successful because of the damage incurred by tumor cells by radiation and the enhanced or preserved presentation of tumor cell antigens by GCLRP-activated immune cells. Monocyte-derived brain cells may be important targets for creating effective immunological modalities such as employing the receptor system described in this study.
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