Idiopathic intracranial hypertension, hormones, and 11ß-hydroxysteroid dehydrogenases

Citations Over TimeTop 10% of 2016 papers

Abstract

Idiopathic intracranial hypertension (IIH) results in raised intracranial pressure (ICP) leading to papilledema, visual dysfunction, and headaches. Obese females of reproductive age are predominantly affected, but the underlying pathological mechanisms behind IIH remain unknown. This review provides an overview of pathogenic factors that could result in IIH with particular focus on hormones and the impact of obesity, including its role in neuroendocrine signaling and driving inflammation. Despite occurring almost exclusively in obese women, there have been a few studies evaluating the mechanisms by which hormones and adipokines exert their effects on ICP regulation in IIH. Research involving 11β-hydroxysteroid dehydrogenase type 1, a modulator of glucocorticoids, suggests a potential role in IIH. Improved understanding of the complex interplay between adipose signaling factors such as adipokines, steroid hormones, and ICP regulation may be key to the understanding and future management of IIH.

Related Papers

• → Adipokines at the crossroads of obesity and mesenchymal stem cell therapy(2023)38 cited
• Adipocytokines and obesity-linked disorders.(2012)
• → Long-term evolution of papilledema in idiopathic intracranial hypertension: observations concerning two cases(2002)8 cited
• → Adipokines, Inflammation, and Obesity(2010)1 cited
• → [Misconceptions in diagnosis and treatment of papilledema caused by idiopathic intracranial hypertension].(2023)