Endometrial Tumors with MSI-H and dMMR Share a Similar Tumor Immune Microenvironment
OncoTargets and Therapy2021Vol. Volume 14, pp. 4485–4497
Citations Over TimeTop 10% of 2021 papers
Abstract
NGS-identified MSI status and IHC-identified MMR status were inconsistent in EC, and 11% of NGS-identified MSI-H tumors retained MMR protein expression. Conversely, MSI and MMR status determined by the two methods provided similar data on TMB, PD-L1 expression, and TIL abundance, which can guide treatment decisions with ICIs.
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