Caveolin-3: Its Importance in Muscle Function and Pathology

Abstract

Caveolae are microdomains of the plasma membrane enriched in cholesterol and glycosphingolipids. Caveolin- 3 is the structural protein component of caveolar membranes in muscle cells. The functional role of caveolin-3 in muscle cells has become more apparent over the last few years as several mutations of the caveolin-3 gene have been linked to muscle diseases, and animal models lacking or over-expressing caveolin-3 have been generated and characterized. In this review we give a summary of the current literature on the genetic mutations of the caveolin-3 gene and their effect on muscle and heart tissue functions, predominantly how it pertains to muscular dystrophy. We will look at how the caveolin- 3 protein regulates signaling pathways in muscle cells and the physiological ramifications of these interactions in normal and pathological conditions. We will also give an overview of the data from genetically engineered mouse models.

Related Papers

• → Identification, sequence, and expression of caveolin-2 defines a caveolin gene family.(1996)558 cited
• → M‐caveolin, a muscle‐specific caveolin‐related protein(1996)242 cited
• → M‐caveolin, a muscle‐specific caveolin‐related protein(1995)192 cited
• → Accumulation of molecules involved in α1-adrenergic signal within caveolae: caveolin expression and the development of cardiac hypertrophy(2001)94 cited
• → A Second Protein Marker of Caveolae: Caveolin-2(2010)9 cited