International Changes in COVID-19 Clinical Trajectories Across 315 Hospitals and 6 Countries: Retrospective Cohort Study
Journal of Medical Internet Research2021Vol. 23(10), pp. e31400–e31400
Citations Over TimeTop 14% of 2021 papers
Griffin M. Weber, Harrison G. Zhang, Sehi L’Yi, Clara-Lea Bonzel, Chuan Hong, Paul Avillach, Alba Gutiérrez‐Sacristán, Nathan Palmer, Amelia L.M. Tan, Xuan Wang, William Yuan, Nils Gehlenborg, Anna Alloni, Danilo F. Amendola, Antonio Bellasi, Riccardo Bellazzi, Michele Beraghi, Mauro Bucalo, Luca Chiovato, Kelly Cho, Arianna Dagliati, Hossein Estiri, Robert W Follett, Noelia García Barrio, David A. Hanauer, Darren W. Henderson, Yuk‐Lam Ho, John H. Holmes, Meghan R. Hutch, Ramakanth Kavuluru, Katie Kirchoff, Jeffrey G. Klann, Ashok Krishnamurthy, Trang T. Le, Molei Liu, Ne Hooi Will Loh, Sara Lozano‐Zahonero, Yuan Luo, Sarah E. Maidlow, Adeline Makoudjou, Alberto Malovini, Marcelo Roberto Martins, Bertrand Moal, Michele Morris, Danielle L. Mowery, Shawn N. Murphy, Antoine Neuraz, Kee Yuan Ngiam, Marina Politi Okoshi, Gilbert S. Omenn, Lav P. Patel, Miguel Pedrera‐Jiménez, Robson Prudente, Malarkodi Jebathilagam Samayamuthu, Fernando J Sanz Vidorreta, Emily Schriver, Petra Schubert, Pablo Serrano Balazote, Byorn W.L. Tan, Suzana Érico Tanni, Valentina Tibollo, Shyam Visweswaran, Kavishwar B. Wagholikar, Zongqi Xia, Daniela Zöller, Isaac S. Kohane, Tianxi Cai, Andrew M. South, Gabriel A. Brat
Abstract
Patients hospitalized in the second wave were at significantly lower risk for severe COVID-19. This corresponded to mean laboratory values in the second wave that were more likely to be in typical physiological ranges on the seventh hospital day compared to the first wave. Our federated approach demonstrated the feasibility and power of harmonizing heterogeneous EHR data from multiple international health care systems to rapidly conduct large-scale studies to characterize how COVID-19 clinical trajectories evolve.
Related Papers
- → Usefulness of Plasma Procalcitonin to Predict Severity in Elderly Patients with Community-Acquired Pneumonia(2013)38 cited
- Evaluation of Serum Procalcitonin in Patients with Systemic Inflammatory Response Syndrome with and without Infection(2009)
- Using the Procalcitonin and C-reactive Protein in the Diagnosis of Infectious Diseases(2013)
- Application of procalcitonin and CRP as prognostic markers in surgery infections(2010)
- Application of procalcitonin and CRP as prognostic markers in surgery infections(2009)