Quá trình trưởng thành của MicroRNA 144 phụ thuộc vào Dicer

Abstract

MicroRNAs are short (~20nt to 25nt long) single – stranded RNA molecules that have emerged as important post- transcriptional regulators of gene expression. The maturation of miRNAs depends on either Dicer or Ago2. In this study, the role of Dicer in miR-144 maturation was investigated. MicroRNA 144 level in Dicer knock out cell lines was determined by real-time PCR. The results showed that miR-144 expression significantly decreased when Dicer was knocked out. This data suggests that the maturation of miR-144 is Dicer dependent.

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