Impairment of the Ubiquitin-Proteasome Pathway Is a Downstream Endoplasmic Reticulum Stress Response Induced by Extracellular Human Islet Amyloid Polypeptide and Contributes to Pancreatic β-Cell Apoptosis
Diabetes2007Vol. 56(9), pp. 2284–2294
Citations Over TimeTop 10% of 2007 papers
Abstract
Our data suggest that ER stress responses are intracellular signaling mechanisms induced by extracellular hIAPP aggregation and that impairment of the ubiquitin-proteasome pathway is implicated in ER stress-mediated pancreatic beta-cell apoptosis.
Related Papers
- → IRE1 signaling increases PERK expression during chronic ER stress(2024)69 cited
- → Autoregulation of the 26S proteasome by in situ ubiquitination(2014)69 cited
- → HECT ubiquitin ligases as accessory proteins of the plant proteasome(2022)17 cited
- [Involvement of unfolded protein responses in neurodegeneration].(2003)
- Ubiquitin-like Protein FAT10-mediated Proteasome Degradation(2014)