Mitochondrial Energetics in the Heart in Obesity-Related Diabetes
Diabetes2007Vol. 56(10), pp. 2457–2466
Citations Over TimeTop 1% of 2007 papers
Sihem Boudina, Sandra Sena, Heather Theobald, Xiaoming Sheng, J. J. Wright, Xia Hu, Salwa Aziz, Josie I. Johnson, Heiko Bugger, Vlad G. Zaha, E. Dale Abel
Abstract
These data demonstrate that mitochondrial uncoupling in the heart in obesity and diabetes is mediated by activation of UCPs independently of changes in expression levels. This likely occurs on the basis of increased delivery of reducing equivalents from beta-oxidation to the electron transport chain, which coupled with decreased oxidative phosphorylation capacity increases ROS production and lipid peroxidation.
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