Common Variants of the Novel Type 2 Diabetes GenesCDKAL1andHHEX/IDEAre Associated With Decreased Pancreatic β-Cell Function
Diabetes2007Vol. 56(12), pp. 3101–3104
Citations Over TimeTop 1% of 2007 papers
Laura Pascoe, Andrea Tura, Sheila K. Patel, Ibrahim M. Ibrahim, Ele Ferrannini, Eleftheria Zeggini, Michael N. Weedon, Andrea Mari, Andrew T. Hattersley, Mark I. McCarthy, Timothy M. Frayling, Mark Walker
Abstract
CDKAL1 and HHEX/IDE diabetes-associated alleles are associated with decreased pancreatic beta-cell function, including decreased beta-cell glucose sensitivity that relates insulin secretion to plasma glucose concentration. We confirmed the association between the FTO allele and increased adiposity, but none of the other novel susceptibility alleles were associated with whole-body insulin sensitivity.
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