Electronegative LDL Impairs Vascular Endothelial Cell Integrity in Diabetes by Disrupting Fibroblast Growth Factor 2 (FGF2) Autoregulation
Diabetes2007Vol. 57(1), pp. 158–166
Citations Over TimeTop 19% of 2007 papers
Jonathan Lu, Wei Jiang, Jun-Hai Yang, Po‐Yuan Chang, Jeffrey P. Walterscheid, Hsin‐Hung Chen, Marco Marcelli, Daming Tang, Yuan-Teh Lee, Warren S.‐L. Liao, Chao-Yuh Yang, Chu‐Huang Chen
Abstract
These findings suggest that FGF2 is the primary initiator of its own expression, which is autoregulated through a novel FGF2-PI3K-Akt loop. Thus, by disrupting FGF2 autoregulation in vascular ECs, L5 may impair reendothelialization and collateralization in diabetes.
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