A Novel Susceptibility Locus for Type 1 Diabetes on Chr12q13 Identified by a Genome-Wide Association Study
Diabetes2008Vol. 57(4), pp. 1143–1146
Citations Over TimeTop 10% of 2008 papers
Håkon Håkonarson, Hui‐Qi Qu, Jonathan P. Bradfield, Luc Marchand, Cecilia E. Kim, Joseph Glessner, Rosemarie Grabs, Tracy Casalunovo, Shayne Taback, Edward C. Frackelton, Andrew W. Eckert, Kiran Annaiah, Margaret L. Lawson, F. George Otieno, Erin Santa, Julie L. Shaner, Ryan M. Smith, Chioma C. Onyiah, Robert Skraban, Rosetta Chiavacci, Luke J. Robinson, Charles A. Stanley, Susan Kirsch, Marcella Devoto, Dimitri Monos, Struan F.A. Grant, Constantin Polychronakos
Abstract
We have discovered a type 1 diabetes locus at 12q13 that is replicated in an independent cohort of type 1 diabetic patients and confers a type 1 diabetes risk comparable with that of the 16p13 locus we recently reported. These two loci are identical to two loci identified by the whole-genome association study of the Wellcome Trust Case-Control Consortium, a parallel independent discovery that adds further support to the validity of the GWA approach.
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