Activation of Peroxisome Proliferator–Activated Receptor (PPAR)δ Promotes Reversal of Multiple Metabolic Abnormalities, Reduces Oxidative Stress, and Increases Fatty Acid Oxidation in Moderately Obese Men
Diabetes2007Vol. 57(2), pp. 332–339
Citations Over TimeTop 10% of 2007 papers
Ulf Risérus, Dennis L. Sprecher, Tony G. Johnson, Eric J. Olson, Sandra Hirschberg, Aixue Liu, Zeke Fang, Priti S. Hegde, Duncan Richards, Leli Sarov-Blat, Jay C. Strum, Samar Basu, Jane Cheeseman, Barbara A. Fielding, Sandy M. Humphreys, Theodore M. Danoff, Niall Moore, Peter R. Murgatroyd, Stephen O’Rahilly, Pauline Sutton, Timothy M. Willson, David G. Hassall, Keith N. Frayn, Fredrik Karpe
Abstract
The PPARdelta agonist GW501516 reverses multiple abnormalities associated with the metabolic syndrome without increasing oxidative stress. The effect is probably caused by increased fat oxidation in skeletal muscle.
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