Common Variation in the FTO Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI
Diabetes2008Vol. 57(5), pp. 1419–1426
Citations Over TimeTop 1% of 2008 papers
Rachel M. Freathy, Nicholas J. Timpson, Debbie A. Lawlor, Anneli Pouta, Yoav Ben‐Shlomo, Aimo Ruokonen, Shah Ebrahim, Beverley M. Shields, Eleftheria Zeggini, Michael N. Weedon, Cecilia M. Lindgren, Hana Lango Allen, David Melzer, Luigi Ferrucci, Giuseppe Paolisso, Matthew Neville, Fredrik Karpe, Colin N.A. Palmer, Andrew D. Morris, Paul Elliott, Marjo‐Riitta Järvelin, George Davey Smith, Mark I. McCarthy, Andrew T. Hattersley, Timothy M. Frayling
Abstract
FTO genotype is associated with metabolic traits to an extent entirely consistent with its effect on BMI. Sample sizes of >12,000 individuals were needed to detect associations at P < 0.05. Our findings highlight the importance of using appropriately powered studies to assess the effects of a known diabetes or obesity variant on secondary traits correlated with these conditions.
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