A Rare Mutation in ABCC8/SUR1 Leading to Altered ATP-Sensitive K+ Channel Activity and β-Cell Glucose Sensing Is Associated With Type 2 Diabetes in Adults
Diabetes2008Vol. 57(6), pp. 1595–1604
Citations Over TimeTop 10% of 2008 papers
Andrei I. Tarasov, Tamara Nicolson, Jean-Pierre Riveline, Tarvinder K. Taneja, Stephen A. Baldwin, Jocelyn M. Baldwin, G. Charpentier, Jean–François Gautier, Philippe Froguel, Martine Vaxillaire, Guy A. Rutter
Abstract
An ABCC8/SUR1 mutation with relatively minor effects on K(ATP) channel activity and beta-cell glucose sensing causes diabetes in adulthood. These data suggest a close correlation between altered SUR1 properties and clinical phenotype.
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