Asian Indians Have Enhanced Skeletal Muscle Mitochondrial Capacity to Produce ATP in Association With Severe Insulin Resistance
Diabetes2008Vol. 57(5), pp. 1166–1175
Citations Over TimeTop 1% of 2008 papers
K. Sreekumaran Nair, Maureen L. Bigelow, Yan W. Asmann, Lisa S. Chow, Jill M. Coenen-Schimke, Katherine A. Klaus, ZengKui Guo, Sreekumar Raghavakaimal, Brian A. Irving
Abstract
Despite being more insulin resistant, diabetic Indians had similar muscle OXPHOS capacity as nondiabetic Indians, demonstrating that diabetes per se does not cause mitochondrial dysfunction. Indians irrespective of their diabetic status had higher OXPHOS capacity than Northern European Americans, although Indians were substantially more insulin resistant, indicating a dissociation between mitochondrial dysfunction and insulin resistance.
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