Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes–Associated Variants
Diabetes2009Vol. 58(9), pp. 2070–2083
Citations Over TimeTop 1% of 2009 papers
Tamara Nicolson, Elisa A. Bellomo, Nadeeja Wijesekara, Merewyn K. Loder, Jocelyn M. Baldwin, Armen V. Gyulkhandanyan, Vasilij Koshkin, Andrei I. Tarasov, Raffaella Carzaniga, Katrin Kronenberger, Tarvinder K. Taneja, Gabriela da Silva Xavier, Sarah Libert, Philippe Froguel, Raphaël Scharfmann, Volodymir Stetsyuk, Philippe Ravassard, Helen Parker, Fiona M. Gribble, Frank Reimann, Robert Sladek, Stephen J. Hughes, Paul R V Johnson, Myriam Masseboeuf, Rémy Burcelin, Stephen A. Baldwin, Ming Liu, Roberto Lara‐Lemus, Peter Arvan, Frans Schuit, Michael B. Wheeler, Fabrice Chimienti, Guy A. Rutter
Abstract
ZnT8 is required for normal insulin crystallization and insulin release in vivo but not, remarkably, in vitro. Defects in the former processes in carriers of the R allele may increase type 2 diabetes risks.
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