Functional Role of Suppressor of Cytokine Signaling 3 Upregulation in Hypothalamic Leptin Resistance and Long-Term Energy Homeostasis

Citations Over TimeTop 10% of 2010 papers

Abstract

Our study establishes that Socs3 upregulation alone in POMC neurons is sufficient to cause leptin resistance and obesity. Socs3 upregulation impairs both STAT3 and mTOR signaling before the onset of obesity. The lack of obesity in mice with upregulated Socs3 in leptin receptor neurons suggests that Socs3's effect on energy balance could be cell type specific. Our study indicates that POMC neurons are important mediators of Socs3's effect on leptin resistance and obesity, but that other cell types or alteration of other signaling regulators could contribute to the development of obesity.

Related Papers

• → Leptin and leptin receptor: Analysis of a structure to function relationship in interaction and evolution from humans to fish(2012)90 cited
• → Normal Leptin Expression, Lower Adipogenic Ability, Decreased Leptin Receptor and Hyposensitivity to Leptin in Adolescent Idiopathic Scoliosis(2012)35 cited
• → Phenotypic Consequences of a Nonsense Mutation in the Leptin Receptor Gene (fak) in Obese Spontaneously Hypertensive Koletsky Rats (SHROB)(1998)55 cited
• → The effect of four weeks restricted diet on serum soluble leptin receptor levels and adipocyte leptin receptor density in normoweight rattus norvegicus strain Wistar(2006)
• → Leptin and leptin receptor expression in patients with breast cancer and fibroadenoma of different hormonal status(2011)