Downregulation of Adipose Glutathione S-Transferase A4 Leads to Increased Protein Carbonylation, Oxidative Stress, and Mitochondrial Dysfunction
Diabetes2010Vol. 59(5), pp. 1132–1142
Citations Over TimeTop 10% of 2010 papers
Jessica Curtis, Paul A. Grimsrud, Wendy S. Wright, Xin Xu, Rocı́o Foncea, David W. Graham, Jonathan R. Brestoff, Brian M. Wiczer, Olga Ilkayeva, Katherine Cianflone, Deborah M. Muoio, Edgar A. Arriaga, David Bernlohr
Abstract
These results indicate that downregulation of GSTA4 in adipose tissue leads to increased protein carbonylation, ROS production, and mitochondrial dysfunction and may contribute to the development of insulin resistance and type 2 diabetes.
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