Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance
Diabetes2011Vol. 60(10), pp. 2588–2597
Citations Over TimeTop 1% of 2011 papers
Francesca Amati, John J. Dubé, Elvis Alvarez-Carnero, Martín M. Edreira, Peter J. Chomentowski, Paul M. Coen, Galen E. Switzer, Perry E. Bickel, Maja Stefanović-Račić, Frederico G. S. Toledo, Bret H. Goodpaster
Abstract
Total myocellular DAGs were markedly higher in highly trained athletes, corresponding with higher insulin sensitivity, and suggest a more complex role for DAGs in insulin action. Our data also provide additional evidence in humans linking ceramides to insulin resistance. Finally, this study provides novel evidence supporting a role for specific skeletal muscle proteins involved in intramyocellular lipids, mitochondrial oxidative capacity, and insulin resistance.
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