Deciphering the Complex Communication Networks That Orchestrate Pancreatic Islet Function

Citations Over TimeTop 10% of 2020 papers

Abstract

Pancreatic islets are clusters of hormone-secreting endocrine cells that rely on intricate cell-cell communication mechanisms for proper function. The importance of multicellular cooperation in islet cell physiology was first noted nearly 30 years ago in seminal studies showing that hormone secretion from endocrine cell types is diminished when these cells are dispersed. These studies showed that reestablishing cellular contacts in so-called pseudoislets caused endocrine cells to regain hormone secretory function. This not only demonstrated that cooperation between islet cells is highly synergistic but also gave birth to the field of pancreatic islet organoids. Here we review recent advances related to the mechanisms of islet cell cross talk. We first describe new developments that revise current notions about purinergic and GABA signaling in islets. Then we comment on novel multicellular imaging studies that are revealing emergent properties of islet communication networks. We finish by highlighting and discussing recent synthetic approaches that use islet organoids of varied cellular composition to interrogate intraislet signaling mechanisms. This reverse engineering of islets not only will shed light on the mechanisms of intraislet signaling and define communication networks but also may guide efforts aimed at restoring islet function and β-cell mass in diabetes.

Related Papers

• → Cell-specific nitrogen responses mediate developmental plasticity(2008)611 cited
• → Improved physiological properties of gravity-enforced reassembled rat and human pancreatic pseudo-islets(2014)56 cited
• → Normal Relationship of β- and Non–β-Cells Not Needed for Successful Islet Transplantation(2007)55 cited
• → Quantification of cells in islets of langerhans using DNA determination(1981)14 cited
• Purified Human Pancreatic Islets, In Vivo Islets Function: Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium.(2015)