The Metabolic Syndrome Is Frequent in Klinefelter’s Syndrome and Is Associated With Abdominal Obesity and Hypogonadism
Diabetes Care2006Vol. 29(7), pp. 1591–1598
Citations Over TimeTop 10% of 2006 papers
Anders Bojesen, Kurt Kristensen, Niels Birkebæk, Jens Fedder, Leif Mosekilde, Eric Bennett, Peter Laurberg, Jan Frystyk, Allan Flyvbjerg, Jens Sandahl Christiansen, Claus Højbjerg Gravholt
Abstract
The prevalence of metabolic syndrome was greatly increased, whereas insulin sensitivity was decreased in Klinefelter's syndrome. Both correlated with truncal obesity. Hypogonadism in Klinefelter's syndrome may cause an unfavorable change in body composition, primarily through increased truncal fat and decreased muscle mass. Testosterone treatment in Klinefelter's syndrome only partly corrected the unfavorable changes observed in untreated Klinefelter's syndrome, perhaps due to insufficient testosterone doses.
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