Leptin Gene Epigenetic Adaptation to Impaired Glucose Metabolism During Pregnancy
Diabetes Care2010Vol. 33(11), pp. 2436–2441
Citations Over TimeTop 1% of 2010 papers
Luigi Bouchard, Stéphanie Thibault, Simon‐Pierre Guay, Marta Santuré, Alexandre Monpetit, Julie St‐Pierre, Patrice Perron, Diane Brisson
Abstract
IGT during pregnancy was associated with leptin gene DNA methylation adaptations with potential functional impacts. These epigenetic changes provide novel mechanisms that could contribute to explaining the detrimental health effects associated with fetal programming, such as long-term increased risk of developing obesity and type 2 diabetes.
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