The Shape of the Glucose Response Curve During an Oral Glucose Tolerance Test Heralds Biomarkers of Type 2 Diabetes Risk in Obese Youth
Diabetes Care2016Vol. 39(8), pp. 1431–1439
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Joon Young Kim, Sara F. Michaliszyn, Alexis Nasr, SoJung Lee, Hala Tfayli, Tamara S. Hannon, Kara S. Hughan, Fida Bacha, Silva Arslanian
Abstract
In obese youth without diabetes, the risk imparted by the monophasic glucose curve compared with biphasic glucose curve, independent of fasting and 2-h glucose and insulin concentrations, is reflected in lower insulin sensitivity and poorer β-cell function, which are two major pathophysiological biomarkers of type 2 diabetes in youth.
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