Exercise Response Variations in Skeletal Muscle PCr Recovery Rate and Insulin Sensitivity Relate to Muscle Epigenomic Profiles in Individuals With Type 2 Diabetes
Diabetes Care2018Vol. 41(10), pp. 2245–2254
Citations Over TimeTop 10% of 2018 papers
Natalie Stephens, Bram Brouwers, Alexey M. Eroshkin, Fanchao Yi, Heather H. Cornnell, Christian Meyer, Bret H. Goodpaster, Richard E. Pratley, Steven R. Smith, Lauren M. Sparks
Abstract
A training response variation for clinical risk factors in individuals with type 2 diabetes is reflected by distinct basal myocellular epigenomic profiles in muscle tissue, some of which are maintained in HSkMCs, suggesting a cell-autonomous underpinning. Our data provide new evidence to potentially shift the diabetes treatment paradigm for individuals who do not benefit from training, such that supplemental treatment can be designed.
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