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Report 31: Estimating the burden of COVID-19 in Damascus, Syria: an analysis of novel data sources to infer mortality under-ascertainment

Spiral (Imperial College London)2020

Citations Over TimeTop 10% of 2020 papers

Sabine van Elsland, O Watson, Mervat Alhaffar, Zaki Mehchy, Charles Whittaker, Zack Akil, Kylie E. C. Ainslie, Marc Baguelin, S Bhatt, Adhiratha Boonyasiri, Olivia Boyd, N Brazeau, Lorenzo Cattarino, Grace Charles, Constanze Ciavarella, Lisa Cooper, Helen Coupland, Zulma M. Cucunubá, Gina Cuomo-Dannenburg, A Djaafara, Christl A. Donnelly, Ilaria Dorigatti, Oliver Eales, van Elsland, Sabine, Richard G. FitzJohn, Fitzjohn, Richard, Flaxman, Seth, Forna, Alpha, Katy A. M. Gaythorpe, Gaythorpe, Katherine, Alexandra B. Hogan, Hamlet, Arran, Hauck, Katharina, Scott M. Hayes, Hayes, Sarah, Hinsley, Wes, Imai, Natsuko, Jeffrey, Benjamin, Johnson, Robert, Jorgensen, David, Daniel J. Laydon, John A. Lees, Thomas A. Mellan, Mellan, Thomas, Mishra, Swapnil, Nedjati Gilani, Gemma, Nouvellet, Pierre, Okell, Lucy, Olivera Mesa, Daniela, Pons Salort, Margarita, Ragonnet-Cronin, Manon, Isaac J. Stopard, Stopard, Isaac, H. Juliette T. Unwin, Unwin, Helena, Verity, Robert, Vollmer, Michaela, Volz, Erik, Walters, Caroline, Yaming Wang, Lilith K. Whittles, Whittles, Lilith, Winskill, Peter, Neil M. Ferguson, Ferguson, Neil, Beals, Emma, Walker, Patrick, Anonymous Authors

Abstract

The COVID-19 pandemic has resulted in substantial mortality worldwide. However, to date, countries in the Middle East and Africa have reported substantially lower mortality rates than in Europe and the Americas. One hypothesis is that these countries have been ‘spared’, but another is that deaths have been under-ascertained (deaths that have been unreported due to any number of reasons, for instance due to limited testing capacity). However, the scale of under-ascertainment is difficult to assess with currently available data. In this analysis, we estimate the potential under-ascertainment of COVID-19 mortality in Damascus, Syria, where all-cause mortality data has been reported between 25th July and 1st August. We fit a mathematical model of COVID-19 transmission to reported COVID-19 deaths in Damascus since the beginning of the pandemic and compare the model-predicted deaths to reported excess deaths. Exploring a range of different assumptions about under-ascertainment, we estimate that only 1.25% of deaths (sensitivity range 1% - 3%) due to COVID-19 are reported in Damascus. Accounting for under-ascertainment also corroborates local reports of exceeded hospital bed capacity. To validate the epidemic dynamics inferred, we leverage community-uploaded obituary certificates as an alternative data source, which confirms extensive mortality under-ascertainment in Damascus between July and August. This level of under-ascertainment suggests that Damascus is at a much later stage in its epidemic than suggested by surveillance reports, which have repo. We estimate that 4,340 (95% CI: 3,250 - 5,540) deaths due to COVID-19 in Damascus may have been missed as of 2nd September 2020. Given that Damascus is likely to have the most robust surveillance in Syria, these findings suggest that other regions of the country could have experienced similar or worse mortality rates due to COVID-19.