Role of oxidative stress and nitric oxide in atherothrombosis
Frontiers in bioscience2008Vol. Volume(13), pp. 5323–5323
Citations Over TimeTop 10% of 2008 papers
Abstract
During the last decade basic and clinical research has highlighted the central role of reactive oxygen species (ROS) in cardiovascular disease. Enhanced production or attenuated degradation of ROS leads to oxidative stress, a process that affects endothelial and vascular function, and contributes to vascular disease. Nitric oxide (NO), a product of the normal endothelium, is a principal determinant of normal endothelial and vascular function. In states of inflammation, NO production by the vasculature increases considerably and, in conjunction with other ROS, contributes to oxidative stress. This review examines the role of oxidative stress and NO in mechanisms of endothelial and vascular dysfunction with an emphasis on atherothrombosis.
Related Papers
- → Endothelial Dysfunction and Hypertension(2016)579 cited
- → Endothelial Dysfunction in Hypercholesterolemia: Mechanisms, Pathophysiological Importance, and Therapeutic Interventions(2000)132 cited
- → Combining nitric oxide and calcium sensing for the detection of endothelial dysfunction(2023)11 cited
- → Role of Endothelium in Regulation of the Brain Microcirculation(2003)2 cited