Helicobacter Pylori associated global gastric cancer burden
Citations Over TimeTop 10% of 2009 papers
Abstract
Helicobacter pylori infection is ubiquitous, infecting close to one-half of the world's population, but its prevalence is declining in developed countries. Chronic H. pylori infection is etiologically linked to gastric adenocarcinoma, especially non-cardia type (63% of all stomach cancer or ~5.5% of the global cancer burden: ~25% of cancers associated with infectious etiology), and to gastric mucosal associated lymphoid tissue (MALT) lymphoma, which accounts for up to 8% of all non-Hodgkin lymphoma. Epidemiological, clinical, and animal studies have established a central role for H. pylori in gastric carcinogenesis and provided insights into the mechanisms and biologic relationships between bacterial infection, host genetics, nutrition, and environmental factors. These discoveries invite strategies to prevent infection to be the logical primary goals in a multi-pronged effort to curtail suffering and death from H. pylori infection-associated cancers.
Related Papers
- → Review article: common misconceptions in the management of Helicobacter pylori-associated gastric MALT-lymphoma(2011)65 cited
- → Treatment outcome of localizedHelicobacter pylori-negative low-grade gastric MALT lymphoma(2010)57 cited
- → Regression of gastric high grade mucosa associated lymphoid tissue (MALT) lymphoma after Helicobacter pylori eradication(2001)76 cited
- → The role of Helicobacter pylori in primary gastric MALT lymphoma(1999)55 cited
- → Successful Treatment of Helicobacter Pylori-Negative Gastric MALT Lymphoma With Rituximab(2006)12 cited