Regulation of neutrophil apoptosis by modulation of PKB/Akt activation
Citations Over TimeTop 20% of 2009 papers
Abstract
The serine/threonine kinase, Akt, also known as PKB (Protein Kinase B) is one important signal transduction pathway that mediates the delay of neutrophil apoptosis caused by inflammatory mediators. Proteins controlled by the PKB/Akt pathway have been reported to prevent or reverse apoptotic-signaling pathways and regulate cell survival. In this review we discuss the role of PKB/Akt activation in the regulation of neutrophil activation during inflammation, and the importance of resolving the inflammatory response by inhibiting PKB/Akt activation and neutrophil survival. Furthermore, we introduce the concept of a dynamic Akt signal complex that is altered when an extracellular signal is initiated such that changes in protein-protein interactions within the Akt signal complex regulates Akt activity and cell survival. Various substrates of PKB/Akt as well as positive and negative regulators of PKB/Akt activation are discussed which in turn inhibit or enhance cellular survival.
Related Papers
- → The activation of Akt/PKB signaling pathway and cell survival(2005)1,872 cited
- → The Akt kinases: Isoform specificity in metabolism and cancer(2009)468 cited
- → Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members(2005)174 cited
- Characterization of Akt overexpression in MiaPaCa-2 cells: prohibitin is an Akt substrate both in vitro and in cells.(2008)
- → Towards an understanding of protein kinase B (PKB/Akt) function in mouse development(2004)