A New Name for Pneumocystis from Humans and New Perspectives on the Host-Pathogen Relationship
Citations Over TimeTop 1% of 2002 papers
Abstract
The disease known as Pneumocystis carinii pneumonia (PCP) is a major cause of illness and death in persons with impaired immune systems. While the genus Pneumocystis has been known to science for nearly a century, understanding of its members remained rudimentary until DNA analysis showed its extensive diversity. Pneumocystis organisms from different host species have very different DNA sequences, indicating multiple species. In recognition of its genetic and functional distinctness, the organism that causes human PCP is now named Pneumocystis jiroveci Frenkel 1999. Changing the organism's name does not preclude the use of the acronym PCP because it can be read "Pneumocystis pneumonia." DNA sequence variation exists among samples of P. jiroveci, a feature that allows reexamination of the relationships between host and pathogen. Instead of lifelong latency, transient colonization may be the rule.
Related Papers
- → Evolution of host range inColeosporium ipomoeae, a plant pathogen with multiple hosts(2016)22 cited
- → The expression of heterologous MAM-7 in Lactobacillus rhamnosus reduces its intrinsic capacity to inhibit colonization of pathogen Vibrio parahaemolyticus in vitro(2016)13 cited
- → Enemies make you stronger: Coevolution between fruit fly host and bacterial pathogen increases postinfection survivorship in the host(2021)7 cited
- → Exploring How a Generalist Pathogen and Within-Host Priority Effects Alter the Risk of Being Infected by a Specialist Pathogen(2022)6 cited
- → A general host–pathogen model with free–living infective stages and differing rates of uptake of the infective stages by infected and susceptible hosts(1999)10 cited